2011年5月3日火曜日
INNS for kinase inhibitors - January 2011
There are two new kinase cheap cialis INNs in the latest WHO list of proposed INNs. (There are other kinase inhibitors in this document, but there are not new INNs/USANs - but if anyone knows anything about pacritinib I'd be glad to hear).
Alisertib a.k.a. MLN-8237 - Millenium's Aurora kinase cheap cialis, InChI key: APEDHRWNPCHTHU-UHFFFAOYSA-N InChI: InChI=1S/C27H19ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35) Phase 2
Cenisertib a.k.a. AS-703569 and R-763 - Merck Serono's Aurora kinase inhibitor, InChI key: KSOVGRCOLZZTPF-QMKUDKLTSA-N InChI=1S/C24H30FN7O/c1-14-11-17(5-6-19(14)32-9-7-31(2)8-10-32)28-24-27-13-18(25)23(30-24)29-21-16-4-3-15(12-16)20(21)22(26)33/h3-6,11,13,15-16,20-21H,7-10,12H2,1-2H3,(H2,26,33)(H2,27,28,29,30)/t15-,16+,20+,21-/m1/s1 Phase 1
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